Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache

Affiliations

• ¹ Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ² Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
• ³ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• ⁴ Boston VA Healthcare System, Boston, MA, USA.
• ⁵ Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.
• ⁶ Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ⁷ Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ⁸ Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
• ⁹ VA Palo Alto Health Care System, Palo Alto, CA, USA.
• ¹⁰ Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
• ¹¹ Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.
• ¹² Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ¹³ Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ¹⁴ Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ¹⁵ Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, USA
• ¹⁶ Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, USA
• ¹⁷ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, USA
• ¹⁸ Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
• ¹⁹ Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, USA
• ²⁰ FORMI, Oslo University Hospital, P.O. 4956 Nydalen, 0424 Oslo, Norway
• ²¹ Department of Neurology, Oslo University Hospital, P.O. 4956 Nydalen, 0424 Oslo, Norway
• ²² Institute of Clinical Medicine, University of Oslo, P.O. 1171 Blindern, 0318 Oslo, Norway
• ²³ Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
• ²⁴ Estonian Genome Center, University of Tartu, Tartu, Estonia
• ²⁵ Division of Endocrinology, Boston Children's Hospital, Boston, USA
• ²⁶ Statens Serum Institut, Dept of Epidemiology Research, Copenhagen, Denmark
• ²⁷ Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
• ²⁸ Illumina, 5200 Illumina Way, San Diego, USA
• ²⁹ Vall d'Hebron Research Institute, Pediatric Neurology, Barcelona, Spain
• ³⁰ Folkhälsan Institute of Genetics, Helsinki, Finland, FI-00290
• ³¹ Neuroscience Center, University of Helsinki, Helsinki, Finland, FI-00014
• ³² Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland, FI-00014
• ³³ 23andMe, Inc., 899 W. Evelyn Avenue, Mountain View, CA, USA
• ³⁴ Inserm Research Center for Epidemiology and Biostatistics (U897), University of Bordeaux, 33076 Bordeaux, France
• ³⁵ Division of Preventive Medicine, Brigham and Women's Hospital, Boston MA 02215
• ³⁶ deCODE Genetics, 101 Reykjavik, Iceland
• ³⁷ Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK
• ³⁸ VU University Amsterdam, Department of Biological Psychology, Amsterdam, the Netherlands, 1081 BT
• ³⁹ Leiden University Medical Centre, Department of Neurology, Leiden, The Netherlands, PO Box 9600, 2300 RC
• ⁴⁰ Department of Neurology, Helsinki University Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland
• ⁴¹ Institute for Stroke and Dementia Research, Klinikum der Universtität München, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 17, 81377 Munich Germany
• ⁴² Department of Neurology and Epileptology, Hertie Institute for Clincal Brain Research, University of Tuebingen
• ⁴³ Karolinska Institutet, Department of Neuroscience, 171 77 Stockholm, Sweden
• ⁴⁴ Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD 4006, Australia
• ⁴⁵ Ulm University, Institute of Human Genetics, 89081 Ulm, Germany
• ⁴⁶ University of Oulu, Center for Life Course Epidemiology and Systems Medicine, Oulu, Finland, Box 5000, Fin-90014 University of Oulu
• ⁴⁷ Department of Twin Research and Genetic Epidemiology, King's College London, London, UK
• ⁴⁸ Dept of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands, 3015 CN
• ⁴⁹ Dept of Radiology, Erasmus University Medical Center, Rotterdam, the Netherlands, 3015 CN
• ⁵⁰ Department of Clinical Chemistry, Fimlab Laboratories, and School of Medicine, University of Tampere, Tampere, Finland, 33520
• ⁵¹ Department of Public Health, University of Helsinki, Helsinki, Finland
• ⁵² Harvard Medical School, Boston MA 02115
• ⁵³ University Duisburg Essen, Essen, Germany
• ⁵⁴ Landspitali University Hospital, 101 Reykjavik, Iceland
• ⁵⁵ VU University Medical Centre, Department of Psychiatry, Amsterdam, the Netherlands, 1081 HL
• ⁵⁶ Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, CB 8134, St. Louis, MO 63110, USA
• ⁵⁷ University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 9700RB
• ⁵⁸ MRC Functional Genomics Unit, Department of Physiology, Anatomy & Genetics, Oxford University, UK
• ⁵⁹ Nuffield Department of Clinical Neuroscience, University of Oxford, UK
• ⁶⁰ Oxford Headache Centre, John Radcliffe Hospital, Oxford, UK
• ⁶¹ Max-Planck-Institute of Psychiatry, Munich, Germany
• ⁶² Christian Albrechts University, Kiel, Germany
• ⁶³ Institute of Human Genetics, Helmholtz Center Munich, Neuherberg, Germany
• ⁶⁴ Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki Finland
• ⁶⁵ National Institute for Health and Welfare, Helsinki, Finland
• ⁶⁶ Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland
• ⁶⁷ Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, USA 02115
• ⁶⁸ Dept of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands, 3015 CN
• ⁶⁹ Dept of Pain Management and Research, Oslo University Hospital, Oslo, 0424 Oslo, Norway
• ⁷⁰ Medical Faculty, University of Oslo, Oslo, 0318 Oslo, Norway
• ⁷¹ Division of Mental Health, Norwegian Institute of Public Health,P.O. Box 4404 Nydalen, Oslo, Norway, NO-0403
• ⁷² Kiel Pain and Headache Center, 24149 Kiel, Germany
• ⁷³ Danish Headache Center, Department of Neurology, Rigshospitalet, Glostrup Hospital, University of Copenhagen, Denmark
• ⁷⁴ Institute of Biological Psychiatry, Mental Health Center Sct. Hans, University of Copenhagen, Roskilde, Denmark
• ⁷⁵ Institute Of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, DK-2100 Copenhagen, Denmark
• ⁷⁶ Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark
• ⁷⁷ iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, DK-2100 Copenhagen, Denmark
• ⁷⁸ Oslo University Hospital and University of Oslo, Oslo, Norway
• ⁷⁹ University of Barcelona, Barcelona, Spain
• ⁸⁰ Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, 6525 XD, The Netherlands
• ⁸¹ Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
• ⁸² National Institute on Aging, Bethesda, USA
• ⁸³ School of Medicine, University of Tampere, Kalevantie
• ⁸⁴ University Medical Center Hamburg-Eppendorf, Hamburg, Germany
• ⁸⁵ Karolinska Institutet, Stockholm, Sweden
• ⁸⁶ VU University, Amsterdam, The Netherlands
• ⁸⁷ Universitat Autònoma de Barcelona, Barcelona, Spain
• ⁸⁸ Sutter Health, Sacramento, USA
• ⁸⁹ Department of Public Health, University of Helsinki, Helsinki, Finland.
• ⁹⁰ Department of Health, National Institute for Health and Welfare, Helsinki, Finland
• ⁹¹ Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland, 20521
• ⁹² Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland, 20521
• ⁹³ Imperial College London, Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE) Centre for Environment and Health, School of Public Health, UK, W2 1PG
• ⁹⁴ University of Oulu, Biocenter Oulu, Finland, Box 5000, Fin-90014 University of Oulu
• ⁹⁵ Oulu University Hospital, Unit of Primary Care, Oulu, Finland, Box 10, Fin-90029 OYS
• ⁹⁶ University Medical Center Hamburg Eppendorf, Institute of Human Genetics, 20246 Hamburg, Germany
• ⁹⁷ Population Health Research Institute, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK
• ⁹⁸ Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
• ⁹⁹ Leiden University Medical Centre, Department of Human Genetics, Leiden, The Netherlands, PO Box 9600, 2300 RC
• ¹⁰⁰ Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
• ¹⁰¹ Statistical and Genomic Epidemiology Laboratory, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, QLD 4059, Australia
• ¹⁰² Department of Neurology, Massachusetts General Hospital, Boston, USA