Low dose combined oral contraceptives induced thrombotic anterior wall myocardial infarction: a case report

BMC Cardiovasc Disord. 2020 Apr 19;20(1):182. doi: 10.1186/s12872-020-01462-9.

Abstract

Background: Combined oral contraceptive pills are associated with an established risk for venous thrombosis; however, their risk for arterial thrombosis remains uncertain, especially with the development of low dose new generations of combined oral contraceptive. Arterial thrombosis is less likely to occur with the use of oral contraceptive pills in the absence of cardiovascular risk factors.

Case presentation: We report a 35-year old female with no cardiovascular risk factors who presented with thrombotic anterior wall myocardial infarction 6 months after using a third generation low dose combined oral contraceptive pills (Marvelon; ethinylestradiol 30 mcg and desogestrel 150 mcg).

Conclusion: Third generation low dose combined oral contraceptives may lead to myocardial infarction in young women, even in the absence of other cardiovascular risk factors.

Keywords: Case report; Myocardial infarction; Oral contraceptives.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anterior Wall Myocardial Infarction / chemically induced*
  • Anterior Wall Myocardial Infarction / diagnostic imaging
  • Anterior Wall Myocardial Infarction / drug therapy
  • Anticoagulants / therapeutic use
  • Contraceptives, Oral, Combined / administration & dosage
  • Contraceptives, Oral, Combined / adverse effects*
  • Contraceptives, Oral, Hormonal / administration & dosage
  • Contraceptives, Oral, Hormonal / adverse effects*
  • Contraceptives, Oral, Synthetic / administration & dosage
  • Contraceptives, Oral, Synthetic / adverse effects*
  • Desogestrel / administration & dosage
  • Desogestrel / adverse effects*
  • Enoxaparin / therapeutic use
  • Female
  • Humans
  • Risk Factors
  • Thrombosis / chemically induced*
  • Thrombosis / diagnostic imaging
  • Thrombosis / drug therapy
  • Treatment Outcome

Substances

  • Anticoagulants
  • Contraceptives, Oral, Combined
  • Contraceptives, Oral, Hormonal
  • Contraceptives, Oral, Synthetic
  • Enoxaparin
  • Desogestrel