Bronchial HPV; the good the bad and the unknown

Paul Zarogoulidis; Stavros Tryfon; Konstantinos Sapalidis; Kosmas Tsakiridis; Sofia Baka; Haidong Huang; Chong Bai; Wolfgang Hohenforst-Schmidt; Dimitris Hatzibougias; Evaggelia Athanasiou; Anastasios Vagionas; Maria Saroglou; Christoforos Kosmidis

doi:10.1016/j.rmcr.2020.101053

Bronchial HPV; the good the bad and the unknown

Respir Med Case Rep. 2020 Apr 7:30:101053. doi: 10.1016/j.rmcr.2020.101053. eCollection 2020.

Affiliations

¹ 3rd Department of Surgery, "AHEPA" University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece.
² Pulmonary Department, (NHS), "G. Papanikolaou" General Hospital, Thessaloniki, Greece.
³ Thoracic Surgery Department, "Interbalkan" European Medical Center, Thessaloniki, Greece.
⁴ Oncology Department, "Interbalkan" European Medical Center, Thessaloniki, Greece.
⁵ Department of Respiratory & Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, PR China.
⁶ Sana Clinic Group Franken, Department of Cardiology / Pulmonology / Intensive Care / Nephrology, "Hof" Clinics, University of Erlangen, Hof, Germany.
⁷ Microdiagnostics Private Pathology and Molecular Laboratory, Thessaloniki, Greece.
⁸ Oncology Department, (NHS), General Hospital of Kavala, Kavala, Greece.

Abstract

Background: Solitary tracheobronchial papilloma (STBP) is a rare benign tumor. Human papilloma virus (HPV) infection is associated with dysplasia and a high risk of carcinoma.

Case 1: Sixty five year old male with hemoptysis and with coilocytic atypia, indicating the presence of HPV.

Case 2: Thirty two year old female with a polypoid villoglandular bronchial structure and no cytoplasmic or nuclear atypia but prominent microvilli.

Discussion: Tissue sample is the best sample in order to determine and distinguish the two entities, local treatment should be considered as first option when possible.

Keywords: Argon plasma; Bronchoscopy; Cruotherapy; EBUS; Jet-ventilation; Surgery; YAG-Laser; hpv.

Publication types

Case Reports