As the number of persons infected with human immunodeficiency virus (HIV) dramatically escalates over the next few years, health care providers will increasingly be involved in their care. A thorough understanding of the broad spectrum of infection, from asymptomatic seropositivity to AIDS-related complex and overt AIDS, will help prepare care providers for the challenges ahead. This article identifies the clinical manifestations of infection, provides management plans for common problems, and discusses psychological and social issues pertinent to the care of HIV-infected adults.