Regulation of microglia by glutamate and its signal pathway in neurodegenerative diseases

Xinyue Zhang; Dan Wang; Bo Zhang; Jie Zhu; Zhulin Zhou; Li Cui

doi:10.1016/j.drudis.2020.04.001

Regulation of microglia by glutamate and its signal pathway in neurodegenerative diseases

Drug Discov Today. 2020 Jun;25(6):1074-1085. doi: 10.1016/j.drudis.2020.04.001. Epub 2020 Apr 19.

Authors

Xinyue Zhang¹, Dan Wang², Bo Zhang³, Jie Zhu⁴, Zhulin Zhou⁵, Li Cui⁶

Affiliations

¹ Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China; Department of Neurobiology, Care Sciences & Society, Division of Neurogeriatrics, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden. Electronic address: [email protected].
² Department of Ophthalmology, the First Hospital of Jilin University, Changchun, China. Electronic address: [email protected].
³ Department of Neurobiology, Care Sciences & Society, Division of Neurogeriatrics, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden; Department of Neurosurgery, The First Hospital of Jilin University, Changchun, China. Electronic address: [email protected].
⁴ Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China; Department of Neurobiology, Care Sciences & Society, Division of Neurogeriatrics, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden. Electronic address: [email protected].
⁵ Department of Neurobiology, Care Sciences & Society, Division of Neurogeriatrics, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden. Electronic address: [email protected].
⁶ Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China. Electronic address: [email protected].

PMID: 32320851
DOI: 10.1016/j.drudis.2020.04.001

Abstract

Microglia are an essential component of the central nervous system (CNS) and are involved in the primary response to microorganisms, neuroinflammation, homeostasis, and tissue regeneration, as well as contributing to the pathogenesis of neurodegenerative diseases. Research has shown that microglial diversity, multifunctionality, and their relationship with glutamate are crucial to determining their roles in these diseases. In this review, we focus on recent progress in determining microglial characteristics and the role of glutamate and its receptors in microglia regulation, which could be a novel therapeutic strategy for neurodegenerative diseases.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Central Nervous System / metabolism
Glutamic Acid / metabolism*
Humans
Inflammation / metabolism
Microglia / metabolism*
Neurodegenerative Diseases / metabolism*
Receptors, Glutamate / metabolism
Signal Transduction / physiology*

Substances

Receptors, Glutamate
Glutamic Acid