Histoplasma capsulatum and Mycobacterium avium co-infection in an immunocompromised patient: Case report and literature review

Rossana Patricia Basso; Vanice Rodrigues Poester; Jussara Maria Silveira; Roseli Stone Vieira; Luisa Dias da Mota; Gabriel Baracy Klafke; Jéssica Nunes Müller; Crislaine Padilha Penna; Júlia Silveira Vianna; Caroline Busatto; Pedro Eduardo Almeida da Silva; Ivy Bastos Ramis; David A Stevens; Melissa Orzechowski Xavier

doi:10.1016/j.mmcr.2020.04.001

Histoplasma capsulatum and Mycobacterium avium co-infection in an immunocompromised patient: Case report and literature review

Med Mycol Case Rep. 2020 Apr 6:28:29-32. doi: 10.1016/j.mmcr.2020.04.001. eCollection 2020 Jun.

Authors

Rossana Patricia Basso^{1

2

3}, Vanice Rodrigues Poester^{1

2}, Jussara Maria Silveira^{1

3}, Roseli Stone Vieira³, Luisa Dias da Mota³, Gabriel Baracy Klafke¹, Jéssica Nunes Müller¹, Crislaine Padilha Penna¹, Júlia Silveira Vianna¹, Caroline Busatto^{1

2}, Pedro Eduardo Almeida da Silva^{1

2}, Ivy Bastos Ramis^{1

2}, David A Stevens^{4

5}, Melissa Orzechowski Xavier^{1

2

4

5}

Affiliations

¹ Faculdade de Medicina, Universidade Federal do Rio Grande (FAMED-FURG), Rio Grande do Sul, RS, Brazil.
² Pós-Graduação em Ciências da Saúde, Faculdade de Medicina (FAMED-FURG), RS, Brazil.
³ Hospital Universitário Dr. Miguel Riet Corrêa Jr. (HU-FURG), Vinculado à Empresa Brasileira de Serviços Hospitalares (EBSERH), Brazil.
⁴ California Institute for Medical Research, San Jose, CA, USA.
⁵ Div. of Infectious Diseases and Geographic Medicine, Stanford University Medical School, Stanford, CA, USA.

Abstract

We report a case of fungal and mycobacterial co-infection in an immunosuppressed patient from Southern Brazil. Histoplasmosis was diagnosed in an AIDS patient admitted to the hospital with nonspecific respiratory signs. However, 4 months post hospital discharge, the patient worsened and a co-infection with Mycobacterium avium was detected. Physicians must consider and investigate a broad spectrum of diseases which can occur as co-infections and which share the same clinical symptoms and signs in immunosuppressed patients.

Keywords: Diagnosis; HIV; Histoplasmosis; Mycobacteriosis; Opportunistic diseases.

Publication types

Case Reports