Diagnostic Accuracy of QuantiFERON-TB Gold Plus Assays in Children and Adolescents with Tuberculosis Disease

J Pediatr. 2020 Aug:223:212-215.e1. doi: 10.1016/j.jpeds.2020.02.025. Epub 2020 Apr 22.

Abstract

In 2016, a new interferon-gamma release assay, QuantiFERON-TB Gold Plus, was introduced. We conducted a cross-sectional multicenter study, involving 158 children and adolescents with tuberculosis disease. The overall sensitivity of the assay was 82.9% (IQR 77.0%-88.8%), indicating that in children this test does not have higher sensitivity than previous generation interferon-gamma release assays.

Keywords: diagnosis; interferon-gamma release assay; pediatrics; sensitivity.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Humans
  • Interferon-gamma Release Tests / methods*
  • Male
  • Mycobacterium tuberculosis / isolation & purification*
  • Retrospective Studies
  • Tuberculin Test / methods
  • Tuberculosis / diagnosis*
  • Tuberculosis / microbiology