Rotavirus and autoimmunity

J Gómez-Rial; I Rivero-Calle; A Salas; F Martinón-Torres

doi:10.1016/j.jinf.2020.04.041

Rotavirus and autoimmunity

J Infect. 2020 Aug;81(2):183-189. doi: 10.1016/j.jinf.2020.04.041. Epub 2020 Apr 30.

Authors

J Gómez-Rial¹, I Rivero-Calle², A Salas³, F Martinón-Torres²

Affiliations

¹ Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS) and Hospital Clínico Universitario and Universidade de Santiago de Compostela (SERGAS), Travesa da Choupana s/n 15706 Galicia, Spain; Laboratorio de Inmunología, Servicio de Análisis Clínicos, Hospital Clínico Universitario Santiago de Compostela (SERGAS), Travesa da Choupana s/n 15706 Galicia, Spain. Electronic address: [email protected].
² Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS) and Hospital Clínico Universitario and Universidade de Santiago de Compostela (SERGAS), Travesa da Choupana s/n 15706 Galicia, Spain; Translational Pediatrics and Infectious Diseases, Department of Pediatrics, Hospital Clínico Universitario de Santiago de Compostela, Travesa da Choupana s/n 15706 Galicia, Spain.
³ Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS) and Hospital Clínico Universitario and Universidade de Santiago de Compostela (SERGAS), Travesa da Choupana s/n 15706 Galicia, Spain; Unidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and GenPoB Research Group, Instituto de Investigaciones Sanitarias (IDIS), Hospital Clínico Universitario de Santiago (SERGAS), Travesa da Choupana s/n 15706 Galicia, Spain.

PMID: 32360880
DOI: 10.1016/j.jinf.2020.04.041

Abstract

Rotavirus, a major etiological agent of acute diarrhea in children worldwide, has historically been linked to autoimmunity. In the last few years, several physiopathological approaches have been proposed to explain the leading mechanism triggering autoimmunity, from the old concept of molecular mimicry to the emerging theory of bystander activation and break of tolerance. Epidemiological and immunological data indicate a strong link between rotavirus infection and two of the autoimmune pathologies with the highest incidence: celiac disease and diabetes. The role for current oral rotavirus vaccines is now being elucidated, with a so far positive protective association demonstrated.

Keywords: Autoimmunity; Celiac Disease; Rotavirus; Type 1 Diabetes; Vaccines.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Autoimmunity
Celiac Disease*
Child
Diarrhea / epidemiology
Humans
Rotavirus Infections* / epidemiology
Rotavirus Vaccines*
Rotavirus* / genetics

Substances

Rotavirus Vaccines