5-Aminosalicylic acid in patients with ulcerative colitis in remission: plasma levels after administration of a new rectal enema

P Gionchetti; A Belluzzi; M Campieri; F Torresan; G M Tabanelli; C Brignola; M Miglioli; L Barbara

5-Aminosalicylic acid in patients with ulcerative colitis in remission: plasma levels after administration of a new rectal enema

Methods Find Exp Clin Pharmacol. 1988 Oct;10(10):667-9.

Authors

P Gionchetti¹, A Belluzzi, M Campieri, F Torresan, G M Tabanelli, C Brignola, M Miglioli, L Barbara

Affiliation

¹ Istituto di Clinica Medica e Gastroenterologia, Policlinico S. Orsola, Bologna, Italy.

PMID: 3236941

Abstract

Plasma levels of total 5-aminosalicylic acid (5-ASA) were determined after a single administration of 2 g and 4 g 5-ASA enemas to 6 patients with ulcerative colitis. The mean plasma levels and AUC values confirmed that the active substance is poorly absorbed by rectal route.

MeSH terms

Adult
Aminosalicylic Acids / administration & dosage
Aminosalicylic Acids / blood*
Aminosalicylic Acids / pharmacokinetics
Colitis, Ulcerative / drug therapy
Colitis, Ulcerative / metabolism*
Enema
Female
Humans
Male
Mesalamine
Middle Aged

Substances

Aminosalicylic Acids
Mesalamine