HSCT provides effective treatment for lymphoproliferative disorders in children with primary immunodeficiency

Giulia Prunotto; Ugonna T Offor; Sujith Samarasinghe; Robert Wynn; Ajay Vora; Ben Carpenter; Claire Gowdy; Kieran McHugh; Kevin P Windebank; Attilio Maria Rovelli; Mary A Slatter; Andrew R Gennery; Paul Veys; Chris M Bacon; Simon Bomken; Giovanna Lucchini

doi:10.1016/j.jaci.2020.03.043

HSCT provides effective treatment for lymphoproliferative disorders in children with primary immunodeficiency

J Allergy Clin Immunol. 2020 Aug;146(2):447-450. doi: 10.1016/j.jaci.2020.03.043. Epub 2020 May 1.

Authors

Giulia Prunotto¹, Ugonna T Offor², Sujith Samarasinghe³, Robert Wynn⁴, Ajay Vora³, Ben Carpenter⁵, Claire Gowdy⁶, Kieran McHugh⁷, Kevin P Windebank⁸, Attilio Maria Rovelli¹, Mary A Slatter⁹, Andrew R Gennery¹⁰, Paul Veys¹¹, Chris M Bacon¹², Simon Bomken², Giovanna Lucchini¹³

Affiliations

¹ Bone Marrow Transplantation Unit, Pediatric Department of Milano-Bicocca University, Monza e Brianza per il Bambino e la sua Mamma Foundation, Monza, Italy.
² Wolfson Childhood Cancer Research Centre, Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom; Department of Paediatric Haematology and Oncology, The Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
³ Haematology Department, Great Ormond Street Hospital NHS Trust, London, United Kingdom.
⁴ Department of Blood and Marrow Transplantation, Royal Manchester Children's Hospital, Manchester, United Kingdom.
⁵ University College London Hospital, London, United Kingdom.
⁶ Department of Radiology, Royal Belfast Hospital for Sick Children, Belfast, United Kingdom.
⁷ Radiology Department, Great Ormond Street Hospital NHS Trust, London, United Kingdom.
⁸ Department of Paediatric Haematology and Oncology, The Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
⁹ Department of Paediatric Immunology and Haematopoietic Stem Cell Transplantation, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
¹⁰ Department of Paediatric Immunology and Haematopoietic Stem Cell Transplantation, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
¹¹ BMT Department, Great Ormond Street Hospital NHS Trust, London, United Kingdom.
¹² Wolfson Childhood Cancer Research Centre, Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom; Department of Cellular Pathology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom.
¹³ BMT Department, Great Ormond Street Hospital NHS Trust, London, United Kingdom. Electronic address: [email protected].

PMID: 32371070
DOI: 10.1016/j.jaci.2020.03.043

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Child
Child, Preschool
Female
Hematopoietic Stem Cell Transplantation*
Humans
Infant
Lymphoproliferative Disorders / therapy*
Male
Primary Immunodeficiency Diseases / therapy*
Treatment Outcome

Grants and funding

MR/S021590/1/MRC_/Medical Research Council/United Kingdom