Persistent BK polyomavirus-DNAemia may warrant cystoscopy to rule out urologic carcinoma: A case report and review of the literature

Alyson Prom; Margaret Jorgenson; Sayee Alagusundaramoorthy; Sandesh Parajuli

doi:10.1111/tid.13316

Persistent BK polyomavirus-DNAemia may warrant cystoscopy to rule out urologic carcinoma: A case report and review of the literature

Transpl Infect Dis. 2020 Oct;22(5):e13316. doi: 10.1111/tid.13316. Epub 2020 May 21.

Authors

Alyson Prom¹, Margaret Jorgenson¹, Sayee Alagusundaramoorthy², Sandesh Parajuli²

Affiliations

¹ Department of Pharmacy, University of Wisconsin Hospital and Clinics, Madison, WI, USA.
² Division of Nephrology, Department of Internal Medicine, University of Wisconsin School of Medicine and Public Health Madison, WI, USA.

PMID: 32386093
DOI: 10.1111/tid.13316

Abstract

There is minimal literature describing the clinical workup of patients with persistent BKPyV-DNAemia despite aggressive immunosuppressive reduction. We present a case herein of persistent BKPyV-DNAemia with significant discordance of BK viruria level in a kidney transplant recipient found to have bladder carcinoma. Based on our findings, we recommend evaluating the urine of patients with persistent BKPyV-DNAemia for BK viruria. If there is significant discordance in the level of BKPyV-DNAemia and viruria, cystoscopy should be pursued to rule out bladder or uroepithelial malignancies.

Keywords: BK polyomavirus-associated nephropathy; BK viruria; BKPyV-DNAemia; Urothelial carcinoma.

Publication types

Case Reports
Review

MeSH terms

BK Virus*
Cystoscopy
Humans
Kidney Transplantation*
Polyomavirus Infections*
Transplant Recipients
Tumor Virus Infections
Urologic Neoplasms*