The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV

Paolo Palma; Margaret McManus; Nicola Cotugno; Salvatore Rocca; Paolo Rossi; Katherine Luzuriaga

doi:10.1016/S2352-3018(20)30100-4

The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV

Lancet HIV. 2020 May;7(5):e359-e365. doi: 10.1016/S2352-3018(20)30100-4.

Authors

Paolo Palma¹, Margaret McManus², Nicola Cotugno³, Salvatore Rocca⁴, Paolo Rossi³, Katherine Luzuriaga⁵

Affiliations

¹ Academic Department of Pediatrics, Research Unit of Perinatal Infections, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address: [email protected].
² Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
³ Academic Department of Pediatrics, Research Unit of Perinatal Infections, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
⁴ Academic Department of Pediatrics, Research Unit of Perinatal Infections, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy.
⁵ Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA; Center for Clinical and Translational Science, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address: [email protected].

Abstract

Several assays have been developed to measure and characterise the replication-competent HIV-1 reservoir, which constitutes the barrier to cure. To date, the application of these assays to studies in children and in limited-resource settings has been minimal, primarily because of their expense, the large required blood volumes, and labour-intensive technologies. For children vertically infected with HIV-1 who initiated suppressive antiretroviral therapy (ART) regimens in infancy, HIV-1-specific antibody concentrations are associated with viral persistence and could be used to estimate the size of the residual latent reservoir on ART. This strategy could be particularly useful for screening children on suppressive ART for enrolment into therapeutic vaccine trials and other protocols aimed at achieving HIV-1 remission.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-HIV Agents / therapeutic use
DNA, Viral / blood
HIV Antibodies / blood*
HIV Infections / drug therapy
HIV Infections / immunology*
HIV Infections / transmission
HIV Infections / virology*
HIV-1 / immunology*
Humans
Infant
Infectious Disease Transmission, Vertical*
Viral Load*

Substances

Anti-HIV Agents
DNA, Viral
HIV Antibodies

Abstract

Publication types

MeSH terms

Substances

Grants and funding