Use of copper-cysteamine nanoparticles to simultaneously enable radiotherapy, oxidative therapy and immunotherapy for melanoma treatment

Qi Zhang; Xiangdong Guo; Yingnan Cheng; Lalit Chudal; Nil Kanatha Pandey; Jieyou Zhang; Lun Ma; Qing Xi; Guangze Yang; Ying Chen; Xin Ran; Chengzhi Wang; Jingyi Zhao; Yan Li; Li Liu; Zhi Yao; Wei Chen; Yuping Ran; Rongxin Zhang

doi:10.1038/s41392-020-0156-4

Use of copper-cysteamine nanoparticles to simultaneously enable radiotherapy, oxidative therapy and immunotherapy for melanoma treatment

Signal Transduct Target Ther. 2020 May 15;5(1):58. doi: 10.1038/s41392-020-0156-4.

Authors

Qi Zhang^#^{1

2}, Xiangdong Guo^#¹, Yingnan Cheng^#¹, Lalit Chudal³, Nil Kanatha Pandey³, Jieyou Zhang¹, Lun Ma³, Qing Xi¹, Guangze Yang¹, Ying Chen⁴, Xin Ran⁵, Chengzhi Wang¹, Jingyi Zhao⁴, Yan Li¹, Li Liu⁶, Zhi Yao¹, Wei Chen⁷, Yuping Ran⁸, Rongxin Zhang^{9

10}

Affiliations

¹ Department of Immunology and Research Center of Basic Medical Sciences, Key Laboratory of Immune Microenvironment and Diseases of Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, 300070, Tianjin, China.
² Institute of Integrative Medicines for Acute Abdominal Diseases, Tianjin Nankai Hospital, 300100, Tianjin, China.
³ Department of Physics, The University of Texas at Arlington, Arlington, TX, 76019-0059, USA.
⁴ Guangdong Province Key Laboratory for Biotechnology Drug Candidates, Institute of Basic Medical Sciences, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, China.
⁵ Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
⁶ Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
⁷ Department of Physics, The University of Texas at Arlington, Arlington, TX, 76019-0059, USA. [email protected].
⁸ Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. [email protected].
⁹ Department of Immunology and Research Center of Basic Medical Sciences, Key Laboratory of Immune Microenvironment and Diseases of Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, 300070, Tianjin, China. [email protected].
¹⁰ Guangdong Province Key Laboratory for Biotechnology Drug Candidates, Institute of Basic Medical Sciences, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, China. [email protected].

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Copper* / chemistry
Copper* / pharmacology
Cysteamine* / chemistry
Cysteamine* / pharmacology
Immunotherapy*
Melanoma, Experimental / immunology
Melanoma, Experimental / metabolism
Melanoma, Experimental / therapy*
Mice
Nanoparticles* / chemistry
Nanoparticles* / therapeutic use
Oxidative Stress* / drug effects
Oxidative Stress* / radiation effects

Substances

Cysteamine
Copper