Abstract
The 2019-2020 Northern Hemisphere influenza vaccine includes antigens from 3c3.A H3N2 viruses; however, over half of circulating H3N2 viruses belong to subclade 3c2.A1b. Here, we analyze antibody responses elicited by the egg-adapted 3c3.A H3N2 vaccine strain in ferrets and humans. We find that this vaccine strain elicits antibodies that have reduced reactivity to a wild-type 3c3.A strain and very limited reactivity to 3c2.A strains, including the currently circulating 3c2.A1b strain.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Animals
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Antibodies, Neutralizing / blood
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Antibodies, Neutralizing / immunology
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Antibodies, Viral / immunology
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Antigens, Viral / chemistry
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Antigens, Viral / immunology*
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Ferrets / immunology
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Hemagglutinin Glycoproteins, Influenza Virus / immunology
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Humans
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Influenza A Virus, H3N2 Subtype / immunology*
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Influenza Vaccines / immunology*
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Ovum / immunology
Substances
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Antibodies, Neutralizing
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Antibodies, Viral
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Antigens, Viral
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Hemagglutinin Glycoproteins, Influenza Virus
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Influenza Vaccines