Could the Inhibition of Endo-Lysosomal Two-Pore Channels (TPCs) by the Natural Flavonoid Naringenin Represent an Option to Fight SARS-CoV-2 Infection?

Front Microbiol. 2020 Apr 30:11:970. doi: 10.3389/fmicb.2020.00970. eCollection 2020.

¹ Unit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, SAPIENZA University of Rome, Rome, Italy.
² Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa, Genoa, Italy.
³ Institute of Biophysics, National Research Council, Genoa, Italy.

No abstract available

Keywords: Naringenin; SARS - CoV; antiviral treatment; endo-lysosomal dysfunction; therapeutic targets; two-pore channel (TPC).