T Cells: Bridge-and-Channel Commute to the White Pulp

Michael Sixt; Tim Lämmermann

doi:10.1016/j.immuni.2020.04.020

T Cells: Bridge-and-Channel Commute to the White Pulp

Immunity. 2020 May 19;52(5):721-723. doi: 10.1016/j.immuni.2020.04.020.

Authors

Michael Sixt¹, Tim Lämmermann²

Affiliations

¹ Institute of Science and Technology Austria (IST Austria), Klosterneuburg, Austria. Electronic address: [email protected].
² Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. Electronic address: [email protected].

PMID: 32433942
DOI: 10.1016/j.immuni.2020.04.020

Abstract

In contrast to lymph nodes, the lymphoid regions of the spleen-the white pulp-are located deep within the organ, yielding the trafficking paths of T cells in the white pulp largely invisible. In an intravital microscopy tour de force reported in this issue of Immunity, Chauveau et al. show that T cells perform unidirectional, perivascular migration through the enigmatic marginal zone bridging channels.

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MeSH terms

Cell Movement
Immunity
Lymph Nodes
Spleen*
T-Lymphocytes*