Clinical profile of symptomatic congenital cytomegalovirus infection: cases from a tertiary hospital in north India

Trop Doct. 2020 Jul;50(3):282-284. doi: 10.1177/0049475520923491. Epub 2020 May 21.

Abstract

We retrospectively analysed the records of nine infants with polymerase chain reaction proven congenital cytomegalovirus (CMV) infection, of which 66% were born preterm. Microcephaly was a universal finding, followed by hepatosplenomegaly in 89%, while chorioretinitis was seen in only 44% cases. The mean age at diagnosis was 3.5 months. Neuroimaging was abnormal in 78%, with ventriculomegaly being the most common finding followed by T2/FLAIR white matter abnormalities, periventricular cysts and intracranial haemorrhage.

Keywords: Cytomegalovirus; TORCH; microcephaly; ventriculomegaly.

MeSH terms

  • Cytomegalovirus / isolation & purification
  • Cytomegalovirus Infections / congenital*
  • Cytomegalovirus Infections / diagnosis
  • Cytomegalovirus Infections / epidemiology
  • Cytomegalovirus Infections / pathology*
  • Female
  • Humans
  • India / epidemiology
  • Infant
  • Infant, Newborn
  • Magnetic Resonance Imaging
  • Male
  • Neuroimaging
  • Retrospective Studies
  • Tertiary Care Centers