We describe 9 patients at a medical center in Detroit, Michigan, USA, with severe acute respiratory syndrome coronavirus 2 and Clostridioides difficile. Both infections can manifest as digestive symptoms and merit screening when assessing patients with diarrhea during the coronavirus disease pandemic. These co-infections also highlight the continued importance of antimicrobial stewardship.
Keywords: COVID-19; Clostridiodes difficile; Detroit; Michigan; SARS-CoV-2; United States; antibiotics; antimicrobial drug resistance; bacteria; bacterial infections; co-infection; coronavirus disease; diarrhea; nosocomial infections; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.