FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice

Protein Cell. 2020 Jul;11(7):534-539. doi: 10.1007/s13238-020-00732-8.

Hongying Gao^{1

2}, Chunwei Zheng³, Jian Du⁴, Yue Wu¹, Yonghui Sun¹, Chunsheng Han^{5

6}, Kehkooi Kee⁷, Yu Rao⁸

¹ MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084, China.
² Tsinghua University-Peking University Joint Center for Life Sciences, Beijing, 100084, China.
³ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100084, China.
⁴ Center for Stem Cell Biology and Regenerative Medicine, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
⁵ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100084, China. [email protected].
⁶ University of Chinese Academy of Sciences, Savaid Medical School, Beijing, 100049, China. [email protected].
⁷ Center for Stem Cell Biology and Regenerative Medicine, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China. [email protected].
⁸ MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084, China. [email protected].

No abstract available

Publication types

Indoles
Ligands
N-methyl-N-(3-((2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino)-methyl)-pyridin-2-yl)-methanesulfonamide
Sulfonamides
Focal Adhesion Kinase 1
Ptk2 protein, mouse