Abstract
We report phylogenetic and mutational analysis of severe acute respiratory syndrome coronavirus 2 virus strains from the Lazio region of Italy and provide information about the dynamics of virus spread. Data suggest effective containment of clade V strains, but subsequently, multiple waves of clade G strains were circulating widely in Europe.
Keywords:
COVID-19; Italy; SARS-CoV-2; coronavirus disease; full genome sequence; phylogenetic tree; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Betacoronavirus / classification
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Betacoronavirus / genetics*
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Betacoronavirus / pathogenicity
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Bronchoalveolar Lavage Fluid / virology
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COVID-19
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COVID-19 Testing
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Clinical Laboratory Techniques / methods
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Coronavirus Infections / diagnosis
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Coronavirus Infections / epidemiology*
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Coronavirus Infections / transmission*
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Coronavirus Infections / virology
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Female
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High-Throughput Nucleotide Sequencing
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Hospitalization
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Humans
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Italy / epidemiology
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Male
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Middle Aged
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Mutation
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Nasopharynx / virology
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Pandemics*
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Phylogeny*
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Pneumonia, Viral / diagnosis
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Pneumonia, Viral / epidemiology*
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Pneumonia, Viral / transmission*
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Pneumonia, Viral / virology
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Prospective Studies
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RNA, Viral / genetics*
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Real-Time Polymerase Chain Reaction
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SARS-CoV-2
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Severity of Illness Index
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Time Factors