Gut Microbiota Features on Nursing Home Admission Are Associated With Subsequent Acquisition of Antibiotic-resistant Organism Colonization

Clin Infect Dis. 2020 Dec 15;71(12):3244-3247. doi: 10.1093/cid/ciaa662.

Abstract

Nursing home (NH) patients often acquire colonization with antibiotic-resistant organisms (AROs). We show that patients exposed to broad-spectrum antibiotics during previous hospitalizations have elevated enterococcal relative abundances on NH admission and higher risk of subsequent ARO acquisition. Our findings suggest that interventions preventing ARO spread should extend beyond NH doors.

Keywords: antibiotic exposure; antibiotic-resistant organisms; genomic epidemiology; intestinal microbiota; skilled nursing facilities.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Anti-Bacterial Agents* / therapeutic use
  • Gastrointestinal Microbiome*
  • Hospitalization
  • Humans
  • Nursing Homes
  • Skilled Nursing Facilities

Substances

  • Anti-Bacterial Agents