Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry

Huan Sun; Yan Li; Peipei Liu; Chengpeng Qiao; Xiaomin Wang; Lianao Wu; Kefang Liu; Yu Hu; Chao Su; Shuguang Tan; Shumei Zou; Guizhen Wu; Jinghua Yan; George Fu Gao; Jianxun Qi; Qihui Wang

doi:10.1080/22221751.2020.1770631

Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry

Emerg Microbes Infect. 2020 Dec;9(1):1238-1241. doi: 10.1080/22221751.2020.1770631.

Authors

Huan Sun¹, Yan Li¹, Peipei Liu², Chengpeng Qiao³, Xiaomin Wang^{1

4}, Lianao Wu^{1

5}, Kefang Liu¹, Yu Hu¹, Chao Su^{1

6}, Shuguang Tan¹, Shumei Zou², Guizhen Wu², Jinghua Yan^{1

3

7}, George Fu Gao¹, Jianxun Qi^{1

7}, Qihui Wang^{1

3}

Affiliations

¹ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, People's Republic of China.
² NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
³ CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
⁴ University of Chinese Academy of Sciences, Beijing, People's Republic of China.
⁵ Institute of Physical Science and Information, Anhui University, Hefei, People's Republic of China.
⁶ College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
⁷ Savaid Medical School, University of Chinese Academy of Sciences, Beijing, People's Republic of China.

No abstract available

Publication types

Letter

MeSH terms

Antiviral Agents / chemistry
Antiviral Agents / pharmacology*
COVID-19 / virology*
Humans
Peptides / pharmacology*
SARS-CoV-2 / drug effects*
SARS-CoV-2 / genetics
SARS-CoV-2 / physiology
Spike Glycoprotein, Coronavirus / chemistry
Spike Glycoprotein, Coronavirus / genetics
Spike Glycoprotein, Coronavirus / metabolism
Virus Internalization / drug effects*

Substances

Antiviral Agents
Peptides
Spike Glycoprotein, Coronavirus

Grants and funding

This work was supported by the Ministry of Science and Technology of the People's Republic of China [2016YFD0500305 and 2018ZX10733403], the Chinese Academy of Sciences [XDB29040302], National Natural Science Foundation of China [81922044, 81973228 and 81673358] and Zhejiang University special scientific research fund for COVID-19 prevention and control [2020XGZX031]. Q.W. is supported by the Youth Innovation Promotion Association CAS [2018119].