Pharmacokinetics of oral l-serine supplementation in a single patient

Danny E Miller; Carlos R Ferreira; Anna I Scott; Irene J Chang

doi:10.1016/j.ymgmr.2020.100607

Pharmacokinetics of oral l-serine supplementation in a single patient

Mol Genet Metab Rep. 2020 May 22:24:100607. doi: 10.1016/j.ymgmr.2020.100607. eCollection 2020 Sep.

Authors

Danny E Miller^{1

2}, Carlos R Ferreira³, Anna I Scott^{4

5}, Irene J Chang²

Affiliations

¹ Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington, USA.
² Department of Pediatrics, Division of Genetic Medicine, University of Washington, Seattle, Washinghton and Seattle Children's Hospital, Seattle, Washington, USA.
³ National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
⁴ Department of Laboratories, Seattle Children's Hospital, Seattle, Washington, USA.
⁵ Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

Abstract

Serine, a non-essential amino acid, has attracted clinical attention because of potential benefit in certain metabolic and neurological disorders. Despite the therapeutic potential, little is known about the pharmacokinetics of l-serine metabolism in humans. Here we present pharmacokinetic data at the time of treatment initiation as well as plasma serine levels during dose escalation from a single individual taking oral l-serine as part of a treatment regimen. Our results show that plasma serine levels rise and fall rapidly after oral l-serine intake, suggesting that the optimal dosing for oral l-serine supplementation is at least three times per day.

Keywords: Serine metabolism; l-serine.