Ketone Bodies Exert Ester-Ordinary Suppression of Bifidobacteria and Th17 Cells

Christine A Olson; Gregory R Lum; Elaine Y Hsiao

doi:10.1016/j.cmet.2020.05.011

Ketone Bodies Exert Ester-Ordinary Suppression of Bifidobacteria and Th17 Cells

Cell Metab. 2020 Jun 2;31(6):1049-1051. doi: 10.1016/j.cmet.2020.05.011.

Authors

Christine A Olson¹, Gregory R Lum¹, Elaine Y Hsiao²

Affiliations

¹ Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
² Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: [email protected].

PMID: 32492391
DOI: 10.1016/j.cmet.2020.05.011

Abstract

The ketogenic diet is used to treat neurological and metabolic symptoms of disease, but the extent of its influences across organ systems remains unclear. Ang et al., 2020 reveal that ketone bodies induced by the diet inhibit specific bacteria of the gut microbiota and suppress pro-inflammatory T cells in the intestine.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Bifidobacterium
Diet, Ketogenic*
Esters
Gastrointestinal Microbiome*
Intestines
Ketone Bodies
Th17 Cells

Substances

Esters
Ketone Bodies

Abstract

Publication types

MeSH terms

Substances

Grants and funding