Building a T cell compartment: how immune cell development shapes function

Nat Rev Immunol. 2020 Aug;20(8):499-506. doi: 10.1038/s41577-020-0332-3. Epub 2020 Jun 3.

Abstract

We are just beginning to understand the diversity of the peripheral T cell compartment, which arises from the specialization of different T cell subsets and the plasticity of individual naive T cells to adopt different fates. Although the progeny of a single T cell can differentiate into many phenotypes following infection, individual T cells are biased towards particular phenotypes. These biases are typically ascribed to random factors that occur during and after antigenic stimulation. However, the T cell compartment does not remain static with age, and shifting immune challenges during ontogeny give rise to T cells with distinct functional properties. Here, we argue that the developmental history of naive T cells creates a 'hidden layer' of diversity that persists into adulthood. Insight into this diversity can provide a new perspective on immunity and immunotherapy across the lifespan.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / immunology
  • Humans
  • Immunity, Cellular / immunology*
  • Immunologic Memory / immunology
  • Mice
  • Receptors, Antigen, T-Cell / immunology
  • T-Lymphocyte Subsets / cytology*
  • T-Lymphocyte Subsets / immunology*

Substances

  • Receptors, Antigen, T-Cell