Hepatitis C in Children and Adolescents of a Brazilian Tertiary Center: Identifying Patients Eligible for Direct-Acting Antivirals

Pediatr Infect Dis J. 2020 Sep;39(9):e276-e278. doi: 10.1097/INF.0000000000002725.

Abstract

We evaluated 113 pediatric patients with chronic hepatitis C from 2009 to 2019 at a Brazilian tertiary center. Seventy patients received pegylated-interferon treatment. The sustained virologic response was 61.4%, and 92.8% reported side effects. Currently, we are following 39 patients with chronic hepatitis C, 24 of whom are eligible for treatment with direct-acting antivirals according to Brazilian recommendations.

MeSH terms

  • Adolescent
  • Antiviral Agents / standards
  • Antiviral Agents / therapeutic use*
  • Brazil
  • Child
  • Child, Preschool
  • Drug Therapy, Combination
  • Female
  • Hepacivirus / drug effects
  • Hepatitis C, Chronic / drug therapy*
  • Humans
  • Infant
  • Infant, Newborn
  • Interferon-alpha / therapeutic use
  • Male
  • Retrospective Studies
  • Sustained Virologic Response*
  • Tertiary Care Centers / statistics & numerical data*

Substances

  • Antiviral Agents
  • Interferon-alpha