Frequency and prognostic impact of ZEB2 H1038 and Q1072 mutations in childhood B-other acute lymphoblastic leukemia

Marketa Zaliova; Eliska Potuckova; Julius Lukes; Lucie Winkowska; Julia Starkova; Iveta Janotova; Lucie Sramkova; Jan Stary; Jan Zuna; Martin Stanulla; Martin Zimmermann; Beat Bornhauser; Jean-Pierre Bourquin; Cornelia Eckert; Gunnar Cario; Jan Trka

doi:10.3324/haematol.2020.249094

Frequency and prognostic impact of ZEB2 H1038 and Q1072 mutations in childhood B-other acute lymphoblastic leukemia

Haematologica. 2021 Mar 1;106(3):886-890. doi: 10.3324/haematol.2020.249094.

Authors

Marketa Zaliova^{1

2

3}, Eliska Potuckova^{1

2}, Julius Lukes^{1

2}, Lucie Winkowska^{1

2}, Julia Starkova^{1

2}, Iveta Janotova³, Lucie Sramkova^{1

2

3}, Jan Stary^{2

3}, Jan Zuna^{1

2

3}, Martin Stanulla⁴, Martin Zimmermann⁴, Beat Bornhauser⁵, Jean-Pierre Bourquin⁵, Cornelia Eckert^{6

7}, Gunnar Cario⁸, Jan Trka^{1

2

3}

Affiliations

¹ CLIP: Childhood Leukemia Investigation Prague, Prague, Czech Republic
² Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic
³ University Hospital Motol, Prague, Czech Republic
⁴ Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
⁵ Division of Pediatric Oncology, University Children's Hospital, Zürich, Switzerland
⁶ Department of Pediatric Oncology/Hematology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
⁷ German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany
⁸ Department of Pediatrics, University Medical Center Schleswig- Holstein, Kiel, Germany

No abstract available

Publication types

Letter

MeSH terms

Humans
Mutation
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / diagnosis
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / epidemiology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / epidemiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / genetics
Prognosis
Zinc Finger E-box Binding Homeobox 2

Substances

ZEB2 protein, human
Zinc Finger E-box Binding Homeobox 2

Grants and funding

Funding: this study was supported by grants from the Czech Health Research Council (NV15-30626A) and Charles University (Primus/MED/28, UNCE 204012) and by the project (Ministry of Health, Czech Republic) for conceptual development of research organization 00064203 (University Hospital Motol, Prague, Czech Republic). The research infrastructure was supported by the Ministry of Education, Youth and Sports (NPU I n. LO1604 and LM2015091).