Notch blockade overcomes endothelial cell-mediated resistance of FLT3/ITD-positive AML progenitors to AC220 treatment

Leukemia. 2021 Feb;35(2):601-605. doi: 10.1038/s41375-020-0893-y. Epub 2020 Jun 8.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzothiazoles / pharmacology*
  • Drug Resistance, Neoplasm*
  • Endothelial Cells / cytology*
  • Endothelial Cells / metabolism
  • Humans
  • Leukemia, Myeloid, Acute / drug therapy*
  • Leukemia, Myeloid, Acute / genetics
  • Leukemia, Myeloid, Acute / metabolism
  • Leukemia, Myeloid, Acute / pathology
  • Mutation*
  • Phenylurea Compounds / pharmacology*
  • Receptors, Notch / antagonists & inhibitors*
  • Tumor Cells, Cultured
  • fms-Like Tyrosine Kinase 3 / antagonists & inhibitors*
  • fms-Like Tyrosine Kinase 3 / genetics

Substances

  • Benzothiazoles
  • Phenylurea Compounds
  • Receptors, Notch
  • quizartinib
  • FLT3 protein, human
  • fms-Like Tyrosine Kinase 3