Validation of the UK myeloma research alliance risk profile, a new clinical prediction model for outcome in patients with newly diagnosed multiple myeloma not eligible for autologous stem cell transplantation; a population-based study from the Danish national multiple myeloma registry

Louise Redder; Tobias W Klausen; Annette Juul Vangsted; Henrik Gregersen; Niels F Andersen; Robert S Pedersen; Agoston G Szabo; Mikael Frederiksen; Ulf C Frølund; Carsten Helleberg; Lene Kongsgaard Nielsen; Per T Pedersen; Morten Salomo; Peter Gimsing; Henrik Frederiksen; Niels Abildgaard

doi:10.1111/bjh.16806

Validation of the UK myeloma research alliance risk profile, a new clinical prediction model for outcome in patients with newly diagnosed multiple myeloma not eligible for autologous stem cell transplantation; a population-based study from the Danish national multiple myeloma registry

Br J Haematol. 2021 Apr;193(1):119-124. doi: 10.1111/bjh.16806. Epub 2020 Jun 9.

Authors

Louise Redder¹, Tobias W Klausen², Annette Juul Vangsted³, Henrik Gregersen⁴, Niels F Andersen⁵, Robert S Pedersen⁶, Agoston G Szabo⁷, Mikael Frederiksen⁸, Ulf C Frølund⁹, Carsten Helleberg², Lene Kongsgaard Nielsen^{1

10}, Per T Pedersen¹¹, Morten Salomo³, Peter Gimsing³, Henrik Frederiksen^{1

12

13}, Niels Abildgaard^{1

12

13}

Affiliations

¹ Department of Haematology, Odense University Hospital, Odense, Denmark.
² Department of Haematology, Herlev Hospital, Herlev, Denmark.
³ Department Haematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
⁴ Department of Haematology, Aalborg University Hospital, Aalborg, Denmark.
⁵ Department of Haematology, Aarhus University Hospital, Aarhus, Denmark.
⁶ Department of Haematology, Holstebro Hospital, Holstebro, Denmark.
⁷ Department of Haematology, Vejle Hospital, Vejle, Denmark.
⁸ Department of Haematology, Hospital of Southern Jutland, Aabenraa, Denmark.
⁹ Department of Haematology, Zealand University Hospital, Roskilde, Denmark.
¹⁰ Department of Internal Medicine and Cardiology, Regional Hospital Viborg, Denmark.
¹¹ Department of Haematology, South-Western Hospital, Esbjerg, Denmark.
¹² Academy of Geriatric Cancer Research (AgeCare), Odense University Hospital, Odense, Denmark.
¹³ Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

PMID: 32515050
DOI: 10.1111/bjh.16806

Abstract

In 2019 the UK Myeloma Research Alliance introduced the Myeloma Risk Profile (MRP) for prediction of outcome in patients with newly diagnosed multiple myeloma (MM), ineligible for autologous stem cell transplantation. To validate the MRP in a population-based setting we performed a study of the entire cohort of transplant ineligible MM patients above 65 years in the Danish National MM Registry. Our data confirmed the value of the MRP. In a cohort of 1,377 patients, the MRP score separated patients into three distinct risk-groups with an observed hazard ratio of 2.91 for early death in high-risk versus low-risk patients.

Keywords: Myeloma Risk Profile; geriatric; multiple myeloma; prognosis; survival.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Angiogenesis Inhibitors / therapeutic use
Antineoplastic Agents / therapeutic use
Antineoplastic Agents, Alkylating / therapeutic use
Case-Control Studies
Clinical Decision Rules
Denmark / epidemiology
Female
Hematopoietic Stem Cell Transplantation / standards*
Humans
Karnofsky Performance Status / statistics & numerical data
Male
Multiple Myeloma / diagnosis
Multiple Myeloma / drug therapy*
Multiple Myeloma / epidemiology
Multiple Myeloma / mortality*
Prognosis
Proportional Hazards Models
Registries
Risk Assessment
Steroids / therapeutic use
Survival Rate / trends
Transplantation, Autologous / standards*

Substances

Angiogenesis Inhibitors
Antineoplastic Agents
Antineoplastic Agents, Alkylating
Steroids

Abstract

Publication types

MeSH terms

Substances

Grants and funding