[The Agreed Experts' Position of the Eurasian Association of Therapists on Some new Mechanisms of COVID-19 Pathways: Focus on Hemostasis, Hemotransfusion Issues and Blood gas Exchange]

G P Arutyunov; N A Koziolova; E I Tarlovskaya; A G Arutyunov; N Yu Grigorjeva; G A Dzhunusbekova; S V Malchikova; N P Mitkovskaya; Ya A Orlova; M M Petrova; A P Rebrov; A S Sisakyan; V V Skibitsky; A B Sugraliev; I V Fomin; A I Chesnikova; I I Shaposhnik

doi:10.18087/cardio.2020.5.n1132

[The Agreed Experts' Position of the Eurasian Association of Therapists on Some new Mechanisms of COVID-19 Pathways: Focus on Hemostasis, Hemotransfusion Issues and Blood gas Exchange]

Kardiologiia. 2020 May 4;60(5):9-19. doi: 10.18087/cardio.2020.5.n1132.

[Article in Russian]

Authors

G P Arutyunov¹, N A Koziolova², E I Tarlovskaya³, A G Arutyunov¹, N Yu Grigorjeva³, G A Dzhunusbekova⁴, S V Malchikova⁵, N P Mitkovskaya⁶, Ya A Orlova⁷, M M Petrova⁸, A P Rebrov⁹, A S Sisakyan¹⁰, V V Skibitsky¹¹, A B Sugraliev¹², I V Fomin³, A I Chesnikova¹³, I I Shaposhnik¹⁴

Affiliations

¹ N. I. Pirogov Russian National Research Medical University, Moscow, Russia.
² Academician E. A. Vagner Perm State Medical University, Perm, Russia.
³ Privolzhsky Research Medical University, Nizhniy Novgorod, Russia.
⁴ Kazakh Medical University of Postgraduate Education, Almaty, Republic of Kazakhstan.
⁵ Kirov State Medical University, Kirov, Russia.
⁶ Belorussian State Medical University, Minsk, Republic of Belarus.
⁷ M. V. Lomonosov Moscow State University, Moscow, Russia.
⁸ V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
⁹ V. I. Razumovsky Saratov State Medical University, Saratov, Russia.
¹⁰ M. Geratsi Erevan State Medical University, Erevan, Armenia.
¹¹ Kuban State Medical University, Krasnodar, Russia.
¹² S. D. Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan.
¹³ Rostov State Medical University, Rostov-on-Don, Russia.
¹⁴ South Ural State Medical University, Chelyabinsk, Russia.

PMID: 32515699
DOI: 10.18087/cardio.2020.5.n1132

Abstract

The article discusses pathogenesis and treatment of COVID-19. The authors presented state-of-the-art insight into hemostatic disorders in patients with COVID-19 and clinical recommendations on prevention of thrombosis and thromboembolism in patients infected with SARS-CoV-2. The article discussed in detail a new hypothesis proposed by Chinese physicians about a new component in the pathogenesis of COVID-19, namely, about the effect of SARS-CoV-2 virus on the hemoglobin beta-chain and the formation of a complex with porphyrin, which results in displacement of the iron ion. Thus, hemoglobin loses the capability for transporting oxygen, which aggravates hypoxia and worsens the prognosis. The article stated rules of hemotransfusion safety in the conditions of COVID-19 pandemic.

MeSH terms

Betacoronavirus
Blood Gas Analysis*
Blood Transfusion*
COVID-19
Coronavirus Infections / physiopathology*
Hemoglobins
Hemostasis*
Humans
Hypoxia
Iron
Pandemics
Pneumonia, Viral / physiopathology*
Porphyrins
SARS-CoV-2

Substances

Hemoglobins
Porphyrins
porphyrin 5,10,15-tris(N-methylpyridinium-4-yl)-20-(1-pyrenyl)-21H,23H-porphyrin
Iron