Heme Catabolism and Bilirubin Production in Readmitted Jaundiced Newborns

M Jeffrey Maisels; Elizabeth A Kring; Mary P Coffey

doi:10.1016/j.jpeds.2020.06.012

Heme Catabolism and Bilirubin Production in Readmitted Jaundiced Newborns

J Pediatr. 2020 Nov:226:285-288. doi: 10.1016/j.jpeds.2020.06.012. Epub 2020 Jun 9.

Authors

M Jeffrey Maisels¹, Elizabeth A Kring², Mary P Coffey³

Affiliations

¹ Department of Pediatrics, Oakland University William Beaumont School of Medicine, Rochester, MI; Department of Pediatrics, Beaumont Children's Hospital, Royal Oak, MI. Electronic address: [email protected].
² Department of Pediatrics, Beaumont Children's Hospital, Royal Oak, MI.
³ Department of Biostatistics, Beaumont Health Research Institute, Royal Oak, MI.

PMID: 32526232
DOI: 10.1016/j.jpeds.2020.06.012

Abstract

We measured end-tidal CO levels in 50 jaundiced newborns readmitted for phototherapy at age 54-244 hours. The median end-tidal CO level was 1.55 ppm, suggesting that hemolysis is not the primary contributor to the hyperbilirubinemia in many readmitted newborns.

Keywords: bilirubin clearance; end-tidal carbon monoxide; neonatal hyperbilirubinemia; phototherapy.

MeSH terms

Biomarkers / blood
Carbon Monoxide / blood*
Female
Heme / metabolism*
Hemolysis*
Humans
Infant, Newborn
Jaundice, Neonatal / blood
Jaundice, Neonatal / etiology*
Jaundice, Neonatal / pathology
Jaundice, Neonatal / therapy
Male
Patient Readmission
Phototherapy

Substances

Biomarkers
Heme
Carbon Monoxide