Cogan's Syndrome: Clinical Presentations and Update on Treatment

Curr Allergy Asthma Rep. 2020 Jun 16;20(9):46. doi: 10.1007/s11882-020-00945-1.

Abstract

Purpose of review: Cogan's syndrome (CS) is a rare systemic vasculitis that can severely affect vision and hearing, which may also have significant systemic effects. Early recognition of this autoimmune disorder and intervention can minimize disabling and irreversible damage.

Recent findings: This article will review the varying clinical presentations of CS and emerging information of systemic disease associated with CS. We will also review recently published promising treatment outcomes using immune modulating medications. As our framework for recognizing the markers of CS and the associated systemic disorders expands, more effective guidelines and treatment options may emerge.

Keywords: Autoimmune disease; Cogan’s syndrome; Hearing loss; Infliximab; Vasculitis.

Publication types

  • Review

MeSH terms

  • Autoimmune Diseases / diagnosis*
  • Autoimmune Diseases / pathology
  • Autoimmune Diseases / therapy*
  • Cogan Syndrome / diagnosis*
  • Cogan Syndrome / pathology
  • Cogan Syndrome / therapy*
  • Humans