Pivotal role of type-1 inositol 1,4,5-trisphosphate receptor for glucagon-induced gluconeogenesis

Vikas Arige; David I Yule

doi:10.1016/j.ceca.2020.102243

Pivotal role of type-1 inositol 1,4,5-trisphosphate receptor for glucagon-induced gluconeogenesis

Cell Calcium. 2020 Sep:90:102243. doi: 10.1016/j.ceca.2020.102243. Epub 2020 Jun 10.

Authors

Vikas Arige¹, David I Yule²

Affiliations

¹ Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, 14642, United States.
² Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, 14642, United States. Electronic address: [email protected].

Abstract

We highlight a recent paper which documents the important role that Ca²⁺ release through type-1 Inositol 1,4,5-trisphosphate receptor (IP₃R1) plays in the acute regulation by glucagon of gluconeogenesis in hepatocytes. The specificity is likely the result of discrete localization close to mitochondria and PKA-dependent phosphorylation of IP₃R1 which enhances Ca²⁺ release.

Keywords: Glucagon signaling; Gluconeogenesis; Hepatocytes; Inositol 1,4,5-trisphosphate receptors; PKA-phosphorylation.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Calcium / metabolism
Calcium Signaling
Glucagon / metabolism*
Gluconeogenesis*
Hepatocytes / metabolism
Humans
Inositol 1,4,5-Trisphosphate Receptors / metabolism*
Models, Biological

Substances

Inositol 1,4,5-Trisphosphate Receptors
Glucagon
Calcium

Grants and funding

R01 DE014756/DE/NIDCR NIH HHS/United States