Use of Chlorogenic Acid against Diabetes Mellitus and Its Complications

J Immunol Res. 2020 May 28:2020:9680508. doi: 10.1155/2020/9680508. eCollection 2020.

Abstract

Chlorogenic acid (CA) is a phenolic compound commonly found in human plant-based diets. CA is the main component of many traditional Chinese medicine preparations, and in recent years, it has been found to have hypoglycemic, hypolipidemic, anti-inflammatory, antioxidant, and other pharmacological properties. Specifically, CA relieves the effects of, and prevents, diabetes mellitus (DM). In addition, CA is also beneficial against complications arising from DM, such as diabetic nephropathy (DN), diabetic retinopathy (DR), and diabetic peripheral neuropathy (DPN). Herein, we review the use of CA in the prevention and treatment of DM and its complications, providing a background for further research and medical uses.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / administration & dosage
  • Chlorogenic Acid / administration & dosage*
  • Diabetes Complications / drug therapy*
  • Diabetes Complications / prevention & control
  • Diabetes Mellitus / drug therapy*
  • Diabetes Mellitus / prevention & control
  • Gene Expression Regulation, Enzymologic / drug effects
  • Glucose / metabolism
  • Humans
  • Hypoglycemic Agents / administration & dosage*
  • Insulin / biosynthesis
  • Insulin Resistance
  • Lipid Metabolism / drug effects
  • Metabolic Networks and Pathways / drug effects
  • Oxidative Stress / drug effects

Substances

  • Antioxidants
  • Hypoglycemic Agents
  • Insulin
  • Chlorogenic Acid
  • Glucose