The Curing Coma Campaign: Framing Initial Scientific Challenges-Proceedings of the First Curing Coma Campaign Scientific Advisory Council Meeting

J Javier Provencio; J Claude Hemphill; Jan Claassen; Brian L Edlow; Raimund Helbok; Paul M Vespa; Michael N Diringer; Len Polizzotto; Lori Shutter; Jose I Suarez; Robert D Stevens; Daniel F Hanley; Yama Akbari; Thomas P Bleck; Melanie Boly; Brandon Foreman; Joseph T Giacino; Jed A Hartings; Theresa Human; Daniel Kondziella; Geoffrey S F Ling; Stephan A Mayer; Molly McNett; David K Menon; Geert Meyfroidt; Martin M Monti; Soojin Park; Nader Pouratian; Louis Puybasset; Benjamin Rohaut; Eric S Rosenthal; Nicholas D Schiff; Tarek Sharshar; Amy Wagner; John Whyte; DaiWai M Olson; Neurocritical Care Society Curing Coma Campaign

doi:10.1007/s12028-020-01028-9

The Curing Coma Campaign: Framing Initial Scientific Challenges-Proceedings of the First Curing Coma Campaign Scientific Advisory Council Meeting

Neurocrit Care. 2020 Aug;33(1):1-12. doi: 10.1007/s12028-020-01028-9.

Authors

J Javier Provencio¹, J Claude Hemphill², Jan Claassen³, Brian L Edlow⁴, Raimund Helbok⁵, Paul M Vespa⁶, Michael N Diringer⁷, Len Polizzotto⁸, Lori Shutter⁹, Jose I Suarez¹⁰, Robert D Stevens¹⁰, Daniel F Hanley¹¹, Yama Akbari¹², Thomas P Bleck¹³, Melanie Boly¹⁴, Brandon Foreman¹⁵, Joseph T Giacino¹⁶, Jed A Hartings¹⁷, Theresa Human¹⁸, Daniel Kondziella¹⁹, Geoffrey S F Ling²⁰, Stephan A Mayer²¹, Molly McNett²², David K Menon²³, Geert Meyfroidt²⁴, Martin M Monti²⁵, Soojin Park³, Nader Pouratian²⁶, Louis Puybasset²⁷, Benjamin Rohaut²⁸, Eric S Rosenthal⁴, Nicholas D Schiff²⁹, Tarek Sharshar^{30

31}, Amy Wagner³², John Whyte³³, DaiWai M Olson³⁴; Neurocritical Care Society Curing Coma Campaign

Affiliations

¹ Department of Neurology and Neuroscience, University of Virginia, Charlottesville, VA, USA.
² Department of Neurology, Zuckerberg San Francisco General Hospital, University of California, San Francisco, Building 1, Room 101, 1001 Potrero Avenue, San Francisco, CA, 94110, USA. [email protected].
³ Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
⁴ Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
⁵ Department of Neurology, Neurocritical Care, Medical University of Innsbruck, Innsbruck, Austria.
⁶ Departments of Neurology and Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
⁷ Department of Neurology, Washington University, Barnes-Jewish Hospital, St Louis, MO, USA.
⁸ Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA.
⁹ Departments of Critical Care Medicine, Neurology, and Neurosurgery, University of Pittsburgh/UPMC Health System, Pittsburgh, PA, USA.
¹⁰ Departments of Anesthesiology and Critical Care Medicine, Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
¹¹ Division of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, USA.
¹² Departments of Neurology, Neurosurgery and the Beckman Laser Institute, University of California-Irvine, Irvine, CA, USA.
¹³ Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
¹⁴ Department of Neurology, University of Wisconsin-Madison, Madison, WI, USA.
¹⁵ Department of Neurology and Rehabilitation Medicine, University of Cincinnati Gardner Neuroscience Institute, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
¹⁶ Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, USA.
¹⁷ Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
¹⁸ Departments of Neurology and Neurosurgery, Washington University, Barnes-Jewish Hospital, St Louis, MO, USA.
¹⁹ Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
²⁰ Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
²¹ Departments of Neurology and Neurosurgery, New York Medical College, Valhalla, NY, USA.
²² College of Nursing, The Ohio State University, Columbus, OH, USA.
²³ Division of Anaesthesia, University of Cambridge, Cambridge, UK.
²⁴ Department and Laboratory of Intensive Care Medicine, University Hospitals Leuven and KU Leuven, Leuven, Belgium.
²⁵ Department of Psychology, University of California, Los Angeles, CA, USA.
²⁶ Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
²⁷ Department of Anesthesiology and Critical Care, Sorbonne University, GRC 29, AP-HP, DMU DREAM, Pitié-Salpêtrière Hospital, 75013, Paris, France.
²⁸ Department of Neurology, Neuro-ICU, Sorbonne University, Pitié-Salpêtrière Hospital, Paris, France.
²⁹ Departments of Neurology, Neuroscience, and Medical Ethics, Weill Cornell Medicine, New York, NY, USA.
³⁰ Neuro-anesthesiology and Intensive Care Medicine, Sainte-Anne Hospital, Paris-Descartes University, Paris, France.
³¹ Experimental Neuropathology, Infection and Epidemiology Department, Institut Pasteur, Paris, France.
³² Department of Physical Medicine and Rehabilitation, Department of Neuroscience, Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA.
³³ Moss Rehabilitation Research Institute, Elkins Park, PA, USA.
³⁴ Department of Neurology and Neurotherapeutics, University of Texas Southwestern, Dallas, TX, USA.

Abstract

Coma and disordered consciousness are common manifestations of acute neurological conditions and are among the most pervasive and challenging aspects of treatment in neurocritical care. Gaps exist in patient assessment, outcome prognostication, and treatment directed specifically at improving consciousness and cognitive recovery. In 2019, the Neurocritical Care Society (NCS) launched the Curing Coma Campaign in order to address the "grand challenge" of improving the management of patients with coma and decreased consciousness. One of the first steps was to bring together a Scientific Advisory Council including coma scientists, neurointensivists, neurorehabilitationists, and implementation experts in order to address the current scientific landscape and begin to develop a framework on how to move forward. This manuscript describes the proceedings of the first Curing Coma Campaign Scientific Advisory Council meeting which occurred in conjunction with the NCS Annual Meeting in October 2019 in Vancouver. Specifically, three major pillars were identified which should be considered: endotyping of coma and disorders of consciousness, biomarkers, and proof-of-concept clinical trials. Each is summarized with regard to current approach, benefits to the patient, family, and clinicians, and next steps. Integration of these three pillars will be essential to the success of the Curing Coma Campaign as will expanding the "curing coma community" to ensure broad participation of clinicians, scientists, and patient advocates with the goal of identifying and implementing treatments to fundamentally improve the outcome of patients.

Keywords: Biomarker; Coma; Consciousness; Endotype; Recovery.

Publication types

Congress

MeSH terms

Advisory Committees
Biomarkers
Clinical Trials as Topic
Coma / classification
Coma / physiopathology
Coma / therapy
Consciousness Disorders / classification
Consciousness Disorders / physiopathology
Consciousness Disorders / therapy*
Critical Care*
Humans
Implementation Science*
Neurological Rehabilitation*
Neurology*
Proof of Concept Study
Stakeholder Participation

Substances

Biomarkers

Abstract

Publication types

MeSH terms

Substances

Grants and funding