Bone and mineral metabolism in adult celiac disease

Am J Gastroenterol. 1988 Mar;83(3):274-7.

Abstract

Bone mineral density (125I photon absorptiometry) was lower in 20 untreated adult celiac patients than in sex- and age-matched controls (p less than 0.001), and plasma alkaline phosphatase, parathyroid hormone, urinary hydroxyproline/creatinine levels were higher than normal (p less than 0.05, less than 0.001, less than 0.05, respectively). Gluten-free diet was started, and the patients were divided randomly into two treatment groups, one which received oral 25-hydroxyvitamin D 50 micrograms/day and one which did not. After 12 months' treatment, bone turnover markers showed a decrease, which did not reach statistical significance, and bone mineral density did not show significant modifications compared with base line in either group. It was found that a gluten-free diet followed for 1 yr can prevent further bone loss, but no significant differences were detected between the two groups.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • 25-Hydroxyvitamin D 2
  • Adolescent
  • Adult
  • Alkaline Phosphatase / analysis
  • Bone and Bones / diagnostic imaging
  • Bone and Bones / metabolism*
  • Celiac Disease / diet therapy
  • Celiac Disease / drug therapy
  • Celiac Disease / metabolism*
  • Creatinine / analysis
  • Ergocalciferols / analogs & derivatives
  • Ergocalciferols / therapeutic use
  • Female
  • Humans
  • Hydroxyproline / urine
  • Iodine Radioisotopes
  • Male
  • Middle Aged
  • Minerals / metabolism*
  • Parathyroid Hormone / blood
  • Radionuclide Imaging

Substances

  • Ergocalciferols
  • Iodine Radioisotopes
  • Minerals
  • Parathyroid Hormone
  • 25-Hydroxyvitamin D 2
  • Creatinine
  • Alkaline Phosphatase
  • Hydroxyproline