Biotinylated platinum(ii) metallacage towards targeted cancer theranostics

Chem Commun (Camb). 2020 Jul 28;56(60):8460-8463. doi: 10.1039/d0cc03824e.

Abstract

A biotinylated metallacage was prepared via metal-coordination-driven self-assembly, combining fluorescence, anti-cancer and targeted properties into a single entity. The metallacage was successfully employed for targeted cell imaging and therapy, offering a platform for cancer theranostics.

MeSH terms

  • Biotin / chemistry*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology
  • Coordination Complexes / therapeutic use
  • Fluorescent Dyes / chemistry
  • Humans
  • Microscopy, Confocal
  • Neoplasms / diagnostic imaging
  • Neoplasms / drug therapy
  • Platinum / chemistry*
  • Theranostic Nanomedicine*

Substances

  • Coordination Complexes
  • Fluorescent Dyes
  • Platinum
  • Biotin