Ro/SSA antigen in human epidermis

Br J Dermatol. 1988 Mar;118(3):363-7. doi: 10.1111/j.1365-2133.1988.tb02429.x.

Abstract

It has been shown previously by an immunofluorescence technique, that whole serum from patients who have anti-Ro/SSA autoantibodies reacts with a component or components of the epidermis. We have now demonstrated by immunoblotting that the antigen identified in human epidermis by anti-Ro/SSA sera is Ro/SSA antigen, and that Ro/SSA antigen is present both in adult and in neonatal epidermis. The presence of this antigen in tissues which are injured in the anti-Ro/SSA-associated syndromes subacute cutaneous lupus erythematosus and neonatal lupus erythematosus supports the hypothesis that anti-Ro/SSA antibodies react with Ro/SSA antigen in the skin and are important in the initiation of tissue damage.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antibodies, Antinuclear / immunology
  • Autoantigens / analysis*
  • Electrophoresis, Polyacrylamide Gel
  • Humans
  • Infant, Newborn
  • Lupus Erythematosus, Cutaneous / immunology
  • Lupus Erythematosus, Discoid / immunology
  • Molecular Weight
  • RNA, Small Cytoplasmic*
  • Ribonucleoproteins*
  • Skin / immunology*

Substances

  • Antibodies, Antinuclear
  • Autoantigens
  • RNA, Small Cytoplasmic
  • RO60 protein, human
  • Ribonucleoproteins
  • SS-A antibodies
  • SS-A antigen