Molecular characterization of ataxia telangiectasia T cell clones. II. The clonal inv(14) in ataxia telangiectasia differs from the inv(14) in T cell lymphoma

F Zhang; M H Stern; G Thomas; A Aurias

doi:10.1007/BF00291726

Molecular characterization of ataxia telangiectasia T cell clones. II. The clonal inv(14) in ataxia telangiectasia differs from the inv(14) in T cell lymphoma

Hum Genet. 1988 Apr;78(4):316-9. doi: 10.1007/BF00291726.

Authors

F Zhang¹, M H Stern, G Thomas, A Aurias

Affiliation

¹ Laboratoire de Génétique des Tumeurs, UA620 CNRS, Institut Curie, Paris, France.

PMID: 3258841
DOI: 10.1007/BF00291726

Abstract

We compared inversions of chromosome 14 in an ataxia telangiectasia clone and in a malignant T cell line (SUP-T1). The R-banding chromosome analysis showed a clear difference between the distal breakpoint of the two inversions. Fine mapping of the distal breakpoint in the ataxia telangiectasia inv(14) was performed by in situ hybridization. We conclude that this breakpoint is centromeric to the immunoglobulin heavy chain locus and to the D14S1 anonymous locus. Our results favor the existence of an unknown oncogene in band 14q32.1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ataxia Telangiectasia / genetics*
Ataxia Telangiectasia / pathology
Chromosome Inversion*
Chromosomes, Human, Pair 14 / ultrastructure*
Clone Cells / ultrastructure
Humans
Male
T-Lymphocytes / pathology*