Genomic Profiling of Evolving Daptomycin Resistance in a Patient with Recurrent Staphylococcus argenteus Sepsis

Antimicrob Agents Chemother. 2020 Sep 21;64(10):e00961-20. doi: 10.1128/AAC.00961-20. Print 2020 Sep 21.

Abstract

Staphylococcus argenteus is a novel staphylococcal species associated with invasive disease. We report the first case of daptomycin/vancomycin-resistant S. argenteus, initially speciated as Staphylococcus aureus, that developed from repeated treatment with daptomycin for a complex vascular graft infection. Whole-genome sequencing of longitudinally collected isolates identified acquisition of MprF S337L, a mutation predicted to increase surface charge and repel cationic molecules.

Keywords: Staphylococcus; Staphylococcus argenteus; antimicrobial resistance; antimicrobial stewardship; whole-genome sequencing.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Proteins
  • Daptomycin* / pharmacology
  • Daptomycin* / therapeutic use
  • Drug Resistance, Bacterial*
  • Genomics
  • Humans
  • Microbial Sensitivity Tests
  • Sepsis*
  • Staphylococcal Infections* / drug therapy
  • Staphylococcus

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Daptomycin

Supplementary concepts

  • Staphylococcus argenteus