Recurrent APC Splice Variant c.835-8A>G in Patients With Unexplained Colorectal Polyposis Fulfilling the Colibactin Mutational Signature

Gastroenterology. 2020 Oct;159(4):1612-1614.e5. doi: 10.1053/j.gastro.2020.06.055. Epub 2020 Jun 27.
No abstract available

Keywords: Bacterial Infection; Hotspot APC Variant; Unexplained Adenomatous Polyposis Coli; pks + E coli..

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma / genetics*
  • Adenoma / pathology
  • Adenomatous Polyposis Coli / genetics*
  • Adenomatous Polyposis Coli / pathology
  • Carcinoma / genetics*
  • Carcinoma / pathology
  • Cohort Studies
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / pathology
  • Genes, APC*
  • Humans
  • Mosaicism
  • Mutation / genetics*
  • Peptides
  • Polyketides

Substances

  • Peptides
  • Polyketides
  • colibactin