Increased CSF levels of IL-1β, IL-6, and ACE in SARS-CoV-2-associated encephalitis

Marta Bodro; Yaroslau Compta; Laura Llansó; Diana Esteller; Antonio Doncel-Moriano; Alex Mesa; Alejandro Rodríguez; Jordi Sarto; Eugenia Martínez-Hernandez; Alexandru Vlagea; Natalia Egri; Xavier Filella; Manuel Morales-Ruiz; Jordi Yagüe; Álex Soriano; Francesc Graus; Felipe García; “Hospital Clínic Infecto-COVID-19” and “Hospital Clínic Neuro-COVID-19” groups

doi:10.1212/NXI.0000000000000821

Increased CSF levels of IL-1β, IL-6, and ACE in SARS-CoV-2-associated encephalitis

Neurol Neuroimmunol Neuroinflamm. 2020 Jul 1;7(5):e821. doi: 10.1212/NXI.0000000000000821. Print 2020 Sep.

Authors

Marta Bodro¹, Yaroslau Compta¹, Laura Llansó², Diana Esteller², Antonio Doncel-Moriano², Alex Mesa², Alejandro Rodríguez², Jordi Sarto², Eugenia Martínez-Hernandez², Alexandru Vlagea², Natalia Egri², Xavier Filella², Manuel Morales-Ruiz², Jordi Yagüe², Álex Soriano², Francesc Graus², Felipe García²; “Hospital Clínic Infecto-COVID-19” and “Hospital Clínic Neuro-COVID-19” groups

Affiliations

¹ From the Infectious Diseases Service (M.B., Á.S., F. García), Hospital Clínic de Barcelona, Catalonia; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) (M.B., Y.C., X.F., M.M.-R., J.Y., Á.S., F. Graus, F. García), Barcelona, Catalonia; Department of Medicine (M.B., Y.C., Á.S., F. García), Universitat de Barcelona, Catalonia; Neurology Service (Y.C., L.L., D.E., A.D.-M., A.R., J.S.), Hospital Clínic de Barcelona, Catalonia; Institut de Neurociències (Y.C.), Maria de Maeztu excellence center, Universitat de Barcelona, Catalonia; Endocrinology and Nutricion Service (A.M.), Hospital Clínic de Barcelona, Catalonia; Immunology Service (A.V., N.E., J.Y.), Centre de Diagnòstic Biomèdic (CDB), Hospital Clínic de Barcelona, Functional Unit of Clinical Immunology, Hospital Sant Joan de Déu & Hospital Clínic, Barcelona, Catalonia; CDB (X.F., M.M.-R.), Hospital Clínic de Barcelona, Barcelona, Catalonia; and Department of Biomedicine (M.M.-R.), Universitat de Barcelona; CIBERehd; Catalonia, Spain. [email protected] [email protected].
² From the Infectious Diseases Service (M.B., Á.S., F. García), Hospital Clínic de Barcelona, Catalonia; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) (M.B., Y.C., X.F., M.M.-R., J.Y., Á.S., F. Graus, F. García), Barcelona, Catalonia; Department of Medicine (M.B., Y.C., Á.S., F. García), Universitat de Barcelona, Catalonia; Neurology Service (Y.C., L.L., D.E., A.D.-M., A.R., J.S.), Hospital Clínic de Barcelona, Catalonia; Institut de Neurociències (Y.C.), Maria de Maeztu excellence center, Universitat de Barcelona, Catalonia; Endocrinology and Nutricion Service (A.M.), Hospital Clínic de Barcelona, Catalonia; Immunology Service (A.V., N.E., J.Y.), Centre de Diagnòstic Biomèdic (CDB), Hospital Clínic de Barcelona, Functional Unit of Clinical Immunology, Hospital Sant Joan de Déu & Hospital Clínic, Barcelona, Catalonia; CDB (X.F., M.M.-R.), Hospital Clínic de Barcelona, Barcelona, Catalonia; and Department of Biomedicine (M.M.-R.), Universitat de Barcelona; CIBERehd; Catalonia, Spain.

No abstract available

Publication types

Case Reports

MeSH terms

Adult
Angiotensin-Converting Enzyme 2
Betacoronavirus* / isolation & purification
Biomarkers / cerebrospinal fluid
COVID-19
Coronavirus Infections / cerebrospinal fluid*
Coronavirus Infections / complications
Coronavirus Infections / diagnosis
Encephalitis / cerebrospinal fluid*
Encephalitis / diagnosis
Encephalitis / etiology
Humans
Interleukin-1beta / cerebrospinal fluid*
Interleukin-6 / cerebrospinal fluid*
Male
Middle Aged
Pandemics
Peptidyl-Dipeptidase A / cerebrospinal fluid*
Pneumonia, Viral / cerebrospinal fluid*
Pneumonia, Viral / complications
Pneumonia, Viral / diagnosis
SARS-CoV-2

Substances

Biomarkers
Interleukin-1beta
Interleukin-6
Peptidyl-Dipeptidase A
ACE2 protein, human
Angiotensin-Converting Enzyme 2