Identification of druggable inhibitory immune checkpoints on Natural Killer cells in COVID-19

Cell Mol Immunol. 2020 Sep;17(9):995-997. doi: 10.1038/s41423-020-0493-9. Epub 2020 Jul 1.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / therapeutic use
  • Apyrase / antagonists & inhibitors
  • Apyrase / genetics
  • Apyrase / immunology
  • B-Lymphocytes / immunology
  • B-Lymphocytes / pathology
  • B7-H1 Antigen / antagonists & inhibitors
  • B7-H1 Antigen / genetics
  • B7-H1 Antigen / immunology
  • Betacoronavirus / immunology
  • Betacoronavirus / pathogenicity*
  • COVID-19
  • Case-Control Studies
  • Coronavirus Infections / drug therapy
  • Coronavirus Infections / genetics
  • Coronavirus Infections / immunology*
  • Coronavirus Infections / virology
  • Gene Expression / drug effects
  • Humans
  • Immunologic Factors / therapeutic use
  • Killer Cells, Natural / drug effects
  • Killer Cells, Natural / immunology
  • Killer Cells, Natural / pathology
  • Molecular Targeted Therapy / methods*
  • NK Cell Lectin-Like Receptor Subfamily C / antagonists & inhibitors
  • NK Cell Lectin-Like Receptor Subfamily C / genetics
  • NK Cell Lectin-Like Receptor Subfamily C / immunology
  • Pandemics
  • Pneumonia / drug therapy
  • Pneumonia / genetics
  • Pneumonia / immunology*
  • Pneumonia / virology
  • Pneumonia, Viral / drug therapy
  • Pneumonia, Viral / genetics
  • Pneumonia, Viral / immunology*
  • Pneumonia, Viral / virology
  • Programmed Cell Death 1 Receptor / antagonists & inhibitors
  • Programmed Cell Death 1 Receptor / genetics
  • Programmed Cell Death 1 Receptor / immunology
  • SARS-CoV-2
  • Severe Acute Respiratory Syndrome / drug therapy
  • Severe Acute Respiratory Syndrome / genetics
  • Severe Acute Respiratory Syndrome / immunology*
  • Severe Acute Respiratory Syndrome / virology
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / pathology

Substances

  • Antiviral Agents
  • B7-H1 Antigen
  • CD274 protein, human
  • Immunologic Factors
  • KLRC1 protein, human
  • NK Cell Lectin-Like Receptor Subfamily C
  • PDCD1 protein, human
  • Programmed Cell Death 1 Receptor
  • Apyrase
  • ENTPD1 protein, human