Abstract
Annually, increasing numbers of OXA-244-producing Escherichia coli in 13 German federal states prompted us to initiate an outbreak investigation. Whole genome sequencing revealed that among 148 isolates analysed, most belonged to sequence type 38 with 62 isolates forming a genetically distinct cluster. Although no epidemiological link could be identified between cases, ongoing investigations suggest non-healthcare associated transmission. A screening-PCR was developed facilitating early detection of ST38 cluster isolates to identify the source and transmission route.
Keywords:
Carbapenemase; Enterobacterales; WGS; whole genome sequencing.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Anti-Bacterial Agents / pharmacology
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Child
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Child, Preschool
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Community-Acquired Infections / epidemiology*
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Escherichia coli / drug effects
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Escherichia coli / genetics
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Escherichia coli / isolation & purification*
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Escherichia coli Infections / diagnosis*
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Escherichia coli Infections / drug therapy
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Escherichia coli Infections / epidemiology*
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Escherichia coli Proteins / genetics
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Germany / epidemiology
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Humans
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Infant
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Male
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Middle Aged
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Polymerase Chain Reaction
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Whole Genome Sequencing / methods*
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beta-Lactamases / genetics
Substances
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Anti-Bacterial Agents
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Escherichia coli Proteins
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beta-Lactamases