Cardiac BIN1 Replacement Therapy Ameliorates Inotropy and Lusitropy in Heart Failure by Regulating Calcium Handling

Jessica Gambardella; Xu Jun Wang; John Ferrara; Marco Bruno Morelli; Gaetano Santulli

doi:10.1016/j.jacbts.2020.03.018

Cardiac BIN1 Replacement Therapy Ameliorates Inotropy and Lusitropy in Heart Failure by Regulating Calcium Handling

JACC Basic Transl Sci. 2020 Jun 22;5(6):579-581. doi: 10.1016/j.jacbts.2020.03.018. eCollection 2020 Jun.

Authors

Jessica Gambardella^{1

2}, Xu Jun Wang^{1

3}, John Ferrara¹, Marco Bruno Morelli^{1

3}, Gaetano Santulli^{1

2

3

4}

Affiliations

¹ Department of Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, New York, New York.
² International Translational Research and Medical Education Consortium, Naples, Italy.
³ Department of Molecular Pharmacology, Einstein-Mount Sinai Diabetes Research Center, Fleischer Institute for Diabetes and Metabolism, Albert Einstein College of Medicine, New York, New York.
⁴ Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.

No abstract available

Keywords: HFpEF; RyR; arrhythmias; cBIN1; calcium handling; diastolic dysfunction; dyads; heart failure; pressure overload; sympathetic overdrive; t-tubule.

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