IL-1α, IL-6, and GM-CSF Are Downstream Mediators of IL-17A that Promote Asymmetric Stem Cell Self-Renewal in Human Keratinocytes

J Invest Dermatol. 2021 Feb;141(2):458-462.e3. doi: 10.1016/j.jid.2020.05.112. Epub 2020 Jul 2.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult Stem Cells / immunology
  • Adult Stem Cells / pathology*
  • Cell Self Renewal / immunology*
  • Cells, Cultured
  • Granulocyte-Macrophage Colony-Stimulating Factor / metabolism
  • Humans
  • Infant, Newborn
  • Interleukin-17 / metabolism*
  • Interleukin-1alpha / metabolism
  • Interleukin-6 / metabolism
  • Keratinocytes / immunology
  • Keratinocytes / pathology*
  • Primary Cell Culture
  • Psoriasis / immunology*
  • Psoriasis / pathology
  • Signal Transduction / immunology
  • Skin / immunology
  • Skin / pathology

Substances

  • IL17A protein, human
  • IL1A protein, human
  • IL6 protein, human
  • Interleukin-17
  • Interleukin-1alpha
  • Interleukin-6
  • Granulocyte-Macrophage Colony-Stimulating Factor