An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo

Christopher M Proctor; Ilke Uguz; Andrea Slezia; Vincenzo Curto; Sahika Inal; Adam Williamson; George G Malliaras

doi:10.1002/adbi.201800270

An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo

Adv Biosyst. 2019 Feb;3(2):e1800270. doi: 10.1002/adbi.201800270. Epub 2018 Nov 27.

Authors

Christopher M Proctor^{1

2}, Ilke Uguz^{2

3}, Andrea Slezia^{4

5}, Vincenzo Curto^{1

2}, Sahika Inal^{2

6}, Adam Williamson^{4

5}, George G Malliaras^{1

2}

Affiliations

¹ Department of Engineering, University of Cambridge, Cambridge, CB3 0FA, UK.
² Department of Bioelectronics, Ecole Nationale Superieure des Mines, CMP-EMSE, MOC, 13541, Gardanne, France.
³ Department of Electrical Engineering, Colombia University, NY, 10027, USA.
⁴ Institut de Neurosciences des Systèmes, Aix Marseille Université, INS, UMR_S 1106, 13005, Marseille, France.
⁵ Neuroengineering Research Group, Interdisciplinary Excellence Center, Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, H-6720, Hungary.
⁶ Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.

PMID: 32627377
DOI: 10.1002/adbi.201800270

Abstract

The challenge of treating neurological disorders has motivated the development of implantable devices that can deliver treatment when and where it is needed. This study presents a novel brain implant capable of electrophoretically delivering drugs and recording local neural activity on the surface of the brain. The drug delivery is made possible by the integration of a microfluidic ion pump (µFIP) into a conformable electrocorticography (ECoG) device with recording cites embedded next to the drug delivery outlets. The µFIP ECoG device can deliver a high capacity of several biologically important cationic species on demand. The therapeutic potential of the device is demonstrated by using it to deliver neurotransmitters in a rodent model while simultaneously recording local neural activity. These developments represent a significant step forward for cortical drug-delivery systems.

Keywords: bioelectronics; drug delivery; electrocorticography; electrophoretic; neuroengineering.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain* / drug effects
Brain* / physiology
Drug Delivery Systems / instrumentation*
Electrocorticography / instrumentation*
Electrocorticography / methods
Electrophoresis / instrumentation
Equipment Design
Male
Mice
Microfluidic Analytical Techniques / instrumentation*
gamma-Aminobutyric Acid / administration & dosage
gamma-Aminobutyric Acid / pharmacology

Substances

gamma-Aminobutyric Acid