MOF Histone Acetyltransferase in Blood Cell Development

Yasmin Serina Secanechia; Christophe Lancrin

doi:10.1016/j.tig.2020.06.010

MOF Histone Acetyltransferase in Blood Cell Development

Trends Genet. 2020 Sep;36(9):632-634. doi: 10.1016/j.tig.2020.06.010. Epub 2020 Jul 3.

Authors

Yasmin Serina Secanechia¹, Christophe Lancrin²

Affiliations

¹ EMBL Rome - Epigenetics and Neurobiology Unit, Via Ramarini 32, 00015 Monterotondo, Italy.
² EMBL Rome - Epigenetics and Neurobiology Unit, Via Ramarini 32, 00015 Monterotondo, Italy. Electronic address: [email protected].

PMID: 32631633
DOI: 10.1016/j.tig.2020.06.010

Abstract

Gene expression is regulated by transcription factors (TFs) and chromatin modifiers such as histone acetyltransferases (HATs). Pessoa Rodrigues et al. revealed the role of the Males absent on the first (MOF) HAT in hematopoietic stem cell (HSC) differentiation into red blood cells. This work raises interesting questions about how MOF controls other hematopoietic differentiation processes.

Keywords: MOF; chromatin modifiers; development; hematopoiesis; histones.

Publication types

Comment

MeSH terms

Blood Cells
Cell Differentiation
Histone Acetyltransferases*
Transcription Factors*

Substances

Transcription Factors
Histone Acetyltransferases