Characteristics and Outcome of Children with Renal Cell Carcinoma: A Narrative Review

Justine N van der Beek; James I Geller; Ronald R de Krijger; Norbert Graf; Kathy Pritchard-Jones; Jarno Drost; Arnauld C Verschuur; Dermot Murphy; Satyajit Ray; Filippo Spreafico; Kristina Dzhuma; Annemieke S Littooij; Barbara Selle; Godelieve A M Tytgat; Marry M van den Heuvel-Eibrink

doi:10.3390/cancers12071776

Characteristics and Outcome of Children with Renal Cell Carcinoma: A Narrative Review

Cancers (Basel). 2020 Jul 3;12(7):1776. doi: 10.3390/cancers12071776.

Authors

Justine N van der Beek^{1

2}, James I Geller³, Ronald R de Krijger^{1

4}, Norbert Graf⁵, Kathy Pritchard-Jones⁶, Jarno Drost^{1

7}, Arnauld C Verschuur⁸, Dermot Murphy⁹, Satyajit Ray⁹, Filippo Spreafico¹⁰, Kristina Dzhuma⁶, Annemieke S Littooij^{1

2}, Barbara Selle¹¹, Godelieve A M Tytgat¹, Marry M van den Heuvel-Eibrink¹

Affiliations

¹ Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.
² Department of Radiology and Nuclear Medicine, University Medical Center Utrecht/Wilhelmina Children's Hospital, Utrecht University, 3584 CX Utrecht, The Netherlands.
³ Division of Oncology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.
⁴ Department of Pathology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
⁵ Department of Pediatric Oncology & Hematology, Saarland University Medical Center and Saarland University Faculty of Medicine, D-66421 Homburg, Germany.
⁶ UCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
⁷ Oncode Institute, 3521 AL Utrecht, The Netherlands.
⁸ Department of Pediatric Oncology, Hôpital d'Enfants de la Timone, APHM, 13005 Marseille, France.
⁹ Department of Paediatric Oncology, Royal Hospital for Children, Glasgow G51 4TF, Scotland, UK.
¹⁰ Pediatric Oncology Unit, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milano, Italy.
¹¹ Department of Pediatric Hematology and Oncology, St. Annastift Children's Hospital, 67065 Ludwigshafen, Germany.

Abstract

Pediatric renal cell carcinoma (RCC) is a rare type of kidney cancer, most commonly occurring in teenagers and young adolescents. Few relatively large series of pediatric RCC have been reported. Knowledge of clinical characteristics, outcome and treatment strategies are often based on the more frequently occurring adult types of RCC. However, published pediatric data suggest that clinical, molecular and histological characteristics of pediatric RCC differ from adult RCC. This paper summarizes reported series consisting of ≥10 RCC pediatric patients in order to create an up-to-date overview of the clinical and histopathological characteristics, treatment and outcome of pediatric RCC patients.

Keywords: outcome; pediatric; renal cell carcinoma; survival; treatment.

Publication types

Review

Grants and funding

341/Stichting Kinderen Kankervrij