Community-Acquired Methicillin-Resistant Staphylococcus aureus ST59 in a Chinese Adult with Meningitis: A Case Report from China

Infect Drug Resist. 2020 Jun 29:13:2011-2016. doi: 10.2147/IDR.S253407. eCollection 2020.

Abstract

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are reported worldwide and are associated with serious outcomes. The majority of CA-MRSA infections are soft tissue and skin infections, and cases with meningitis caused by CA-MRSA are rare. Here, we reported a 53-year-old male patient with meningitis due to CA-MRSA infection, as confirmed by cerebrospinal fluid examination. Whole-genome sequencing data revealed an ST59 CA-MRSA strain encoding PVL and SCCmec IV. Linezolid was administered in this case, and the patient recovered, with no signs of relapse during the one-year follow-up. We present the first case of PVL-positive ST59 CA-MRSA meningitis, with severe manifestations in China.

Keywords: ST59; community-acquired; meningitis; methicillin-resistant Staphylococcus aureus; whole-genome sequencing.

Publication types

  • Case Reports

Grants and funding

This study was supported by the National Natural Science Foundation of China (31600108) and Zhejiang Provincial Natural Science Foundation (LQY18H190001).